Using a 2-arm, RCT approach, the primary goal of the study is to evaluate the feasibility and preliminary efficacy of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and cognitive risks in older adults. Next, investigators will examine secondary effects of IMST on mood, sleep quality, systemic inflammation, and physical/motor function. Finally, investigators will assess participant adherence and acceptability ratings of using an 8-week home-based IMST protocol in a diverse older adult sample.
Ages 60-80
Converted telephone MoCA total score≥18
Presence of at least one dementia risk factor (e.g., MCI or subjective cognitive decline, hypertension [SBP >130 mmHg or on medication], sedentary lifestyle [<150 min/week], family history of dementia or self-reported APOE ε4 carrier, or mild sleep-disordered breathing; CAIDE total score [>5]
Capable of independently completing or requiring minimal assistance with inspiratory muscle strength training (IMST)
tMoCA <18, or diagnosis of neurodegenerative illness at the discretion of principal investigator (except MCI)
Current evidence of any major psychiatric disorder including psychosis (at the discretion of principal investigator), bipolar disorder, severe major depression (PHQ-9 > 20)
Unstable cardiovascular or pulmonary disease
Recent respiratory therapy or major medication changes
Florida State University
Lead sponsor
National Institutes of Health (NIH)
Collaborator