Incidence of Postoperative Cognitive Decline in Patients With Preexisting Cognitive Impairment

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age60+
SponsorPeking University Shenzhen Hospital

About this trial

This study aims to find out how often memory and thinking problems happen after surgery in people who already have memory issues before their operation. These memory problems are called postoperative cognitive decline (POCD). Older adults with memory problems before surgery may be more likely to have trouble with thinking, memory, and daily activities after their operation. This study will follow patients who already have memory problems before surgery and see how their thinking and memory change after surgery. The results will help doctors better understand how to care for these patients before, during, and after surgery.

Eligibility criteria

Qualifiers

Preexisting Cognitive Impairment (PreCI) Surgical Group

Age ≥ 60 years

Preoperative screening with MMSE and MoCA-B indicating mild cognitive impairment (MCI) or mild dementia

Undergoing elective non-cardiac surgery under general anesthesia

Disqualifiers

Expected difficulty in completing neuropsychological assessments (e.g., inability to communicate in Mandarin, blindness, or deafness)

Usual residence outside Shenzhen

Normative Reference Group

Age ≥ 60 years

Trial design

Treatments tested in this trial

  • surgery
  • norma

Treatment groups

340 Participants
are divided into 2 treatment groups