Objectives: To investigate the efficacy and safety of single daily icodextrin exchange for initiation of incremental peritoneal dialysis (PD).
Subjects: Seventy-two incident PD patients.
Methods: A single-center randomized controlled trial.
Primary outcome: Change in residual kidney function in 48 weeks after recruitment.
male or female patients aged 18 to 75 years;
patients with chronic kidney disease stage 5 who are to start PD;
eGFR ≥ 5 ml/min;
urine output ≥ 800 ml/d.
documented anaphylaxis with icodextrin or glucose-based dialysate;
concomitant severe chronic diseases such as malignancy, hepatitis, severe cardiac diseases, etc.;
ongoing severe infection;
planned or ongoing pregnancy or lactation;