Individual Differences in Gait and Osteoarthritis Pain
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age45-80
SponsorUniversity of Pittsburgh
About this trial
The goal of this observational study is to look at inter-individual differences in knee osteoarthritis (OA) walking pain and performance. The main questions this study aims to answer are:
Why do some people with knee osteoarthritis have more severe disabling pain than others, even though the degenerative changes in their knees are similar?
What are the factors that contribute to walking pain in people with knee osteoarthritis?
Participants will complete surveys, perform physical function tasks, get a knee X-ray and MRI, undergo non-invasive brain imaging, and undergo sensory testing.
Eligibility criteria
Qualifiers
Knee pain for greater than 6 months.
Moderate-to-severe knee pain (>3/10) due to osteoarthritis, as defined by American College of Rheumatology and EULAR diagnostic criteria, on >50% of days in the past month.
KL grade 2-4 indicating significant degenerative changes on knee X-ray.
45-80 years old
Disqualifiers
Inflammatory arthritis (e.g. rheumatoid arthritis).
More intense pain due to another chronic pain syndrome (e.g. fibromyalgia, hip osteoarthritis)
Significant pain or weakness in the lower extremities due to a neurological condition (e.g. lumbar radiculopathy, paresis due to stroke)
Acute pain that is more intense than knee osteoarthritis pain
Trial design
Treatments tested in this trial
- Not listed
Trial groups
300 Participants
are grouped into 1 trial groupSponsors and collaborators
University of Pittsburgh
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborator
Source ClinicalTrials.gov