This prospective, single-center, randomized controlled trial aims to evaluate the efficacy of an intraoperative "Individualized Open Lung Ventilation" strategy compared to a standard lung-protective ventilation strategy in patients undergoing thoracic surgery.
One-lung ventilation (OLV) is essential for thoracic surgery but can cause lung injury. While standard care often uses fixed ventilation parameters, this study investigates whether personalizing Positive End-Expiratory Pressure (PEEP) to achieve the lowest driving pressure can reduce the incidence of postoperative pulmonary complications (PPCs) within 7 days after surgery.
Age 18 to 75 years.
American Society of Anesthesiologists (ASA) physical status I-III.
Body mass index between 18 and 30 kg/m².
Scheduled for elective video-assisted thoracoscopic surgery (VATS).
Pregnancy or breastfeeding.
Emergency surgery or reoperation.
History of severe pulmonary disease, including chronic obstructive pulmonary disease, pulmonary fibrosis, severe emphysema, pulmonary bullae, pneumothorax, or uncontrolled asthma.
History of heart failure or coronary artery disease.