This study is designed to obtain preliminary data comparing indwelling pleural catheters (IPCs) versus IPCs plus doxycycline for pleurodesis as treatments for malignant pleural effusion (MPE). Indwelling pleural catheters (IPCs) are commonly used to treat pleural effusions (build-up of fluid in the lungs). Doxycycline is an antibiotic that is also used to treat pleural effusions. The goal of this clinical research study is to learn if adding doxycycline to the use of an IPC can lead to shorter treatment times with IPCs.
Outpatients with MPE undergoing IPC placement
Sufficient mental capacity to provide informed consent and answer Short-Form Six-Dimension health index (SF-6D) and Borg score questions
Inpatients that are expected to be discharged within 5 days of receiving an indwelling pleural catheter
Patients undergoing pleurodesis for benign disease (e.g., spontaneous pneumothorax)
Inability or unwillingness to give informed consent
Inability to perform phone call and clinical follow-up at MD Anderson Cancer Center (MDACC)
Pregnancy
M.D. Anderson Cancer Center
Lead sponsor
National Cancer Institute (NCI)
Collaborator