INflammation and Small Vessel Disease Study
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age40+
SponsorUniversity of Cambridge
About this trial
A prospective observational cohort study in patients with cerebral small vessel disease deterring whether changes in systemic inflammation predict brain white matter damage measured using MRI and cognitive decline. This is a study funded by a joint BHF-Dutch Heart Foundation research grant and will be conducted in both Cambridge UK and Nijmegen Netherlands with 100 of the 200 total participants recruited at each site, and data from both sites analysed together.
Eligibility criteria
Qualifiers
Have given written informed consent to participate
Be aged 40 years and over
Clinical lacunar stroke syndrome with lacunar infarct, as defined by the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) criteria
And/OR Symptoms of cognitive impairment due to SVD with lacunar infarct on MRI
Disqualifiers
Unable/unwilling to consent including lack of capacity to consent
Contraindications to taking part in MRI study as assessed by the local MRI safety questionnaire, e.g., pacemaker
Vaccination or infection with fever in preceding month
Cardioembolic source
Trial design
Treatments tested in this trial
- Not listed
Trial groups
200 Participants
are grouped into 1 trial groupSponsors and collaborators
University of Cambridge
Lead sponsor
Radboud University Medical Center
Collaborator
Wolfson Brain Imaging Centre
Collaborator
Source ClinicalTrials.gov