This study aims to examine three key aspects of chronic rhinosinusitis with nasal polyps (CRSwNP): inflammation, tissue structure (histopathology), and remodeling.
Must be ≥19 of age at the time of signing the informed consent form
Capable of giving signed informed consent.
Having CRSwNP based on clinical symptoms and/or radiographic or endoscopic evidence of inflammation in their upper airways (Diagnosis consistent with EPOS 2020)2 and nasal polyp score (NPS) of at least 2 on each side
Not expecting to have surgery within the next 7 months
A history of organ transplantation such as lung transplantation
Previously or currently using immunomodulator or allergy medications or (including The allergy medications such as: a) First and second generations of Antihistamines (H1 blockers); b) Oral/Topical Decongestants; c) Oral or systemic corticosteroids; d) Leukotriene Receptor Antagonists; e) Mast Cell Stabilizers.
A history of auto-immune diseases such as Rheumatoid arthritis and Systemic lupus erythematosus,
Current or past sinonasal or bronchial tumors