About this trial
The main objective is to evaluate the FreeO2 device combined with noninvasive respiratory support technique for COPD patients and postoperative bariatric surgery patients.
The main hypothesis is that FreeO2 device for oxygen therapy associated with NIV or nasal high flow oxygen therapy (NHFOT) allows to reach better oxygenation and avoid hypoxemia and hyperoxia.
Eligibility criteria
Qualifiers
Respiratory acidosis (pH <= 7.35 and PaCO2 > 45 mmHg), with or without NIV (last blood gas available during hospitalization)
Oxygen therapy and/or SpO2 <90% room air (FiO2 <= 50% or nasal cannula <= 7 L/min to maintain SpO2 90%)
High flow nasal cannula with flow <= 30 L/min
Patients using CPAP before the surgery (obstructive sleep apnea documented).
Disqualifiers
Age < 18
Pregnancy
Respiratory distress or other clinical situation requiring continuous NIV or CPAP
Glasgow < 12 or agitation/delirium/dementia (limiting NIV)
Trial design
Treatments tested in this trial
- Washout period
- NIV - FreeO2
- Nasal High flow Oxygen therapy - FreeO2
- CPAP - Oxygen constant flow
- CPAP - FreeO2
Treatment groups
Sponsors and collaborators
François Lellouche
Lead sponsor
Laval University
Sponsor institution