Influence of Menstrual Cycle Phase on Adaptations to Sprint Interval Training
ConditionHealthy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-35
SponsorUniversity of Toronto
About this trial
Sprint interval training improves endurance performance and induces metabolic adaptations in muscle. Most research demonstrating these responses has been conducted in males, with limited studies evaluating changes to endurance performance and skeletal muscle oxidative capacity in females. Moreover, it is currently unknown if training in specific phases of the menstrual cycle influences adaptations to training. Thus, the purpose of the present study is to compare adaptations to 2 weeks of sprint interval training performed in the follicular vs. luteal phase of the menstrual cycle in healthy, eumenorrheic women.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Participating in 150 min of moderate-vigorous physical activity/week
VO2peak of 'good' or above based on American College of Sport Medicine (ACSM) normative values(greater than 35.0ml/kg/min)
Body mass index (BMI) between 18-27 kg/m2
Performing 2-4 structured exercise sessions/week.
Disqualifiers
Hormonal contraceptive use within the last 3 months
Polycystic ovarian syndrome (PCOS) or endometriosis
Failure to meet MC verification criteria.
Diagnosed with cardiovascular or metabolic disease, hyper- or hypogonadism, and/or PCOS
Trial design
Design model
Parallel
Treatments tested in this trial
Sprint Interval Training
Other intervention6 sessions of sprint interval training over 2 weeks. Each session involves 4-6 x 30 second Wingate sprints with 4 minutes of recovery in between on a stationary bike
Treatment groups
24 Participants
are divided into 2 treatment groupsGroup A: Follicular Phase TrainingActive comparator 1 intervention
Group B: Luteal Phase TrainingExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Endurance performance
Time to completion and average power output during a 250kJ time trial
Time frame
Before and after 2 weeks of exercise trainingSecondary outcomes
1
Skeletal muscle mitochondrial content
Measured via Western blotting
Time frame
Before and after 2 weeks of exercise training2
Skeletal muscle mitochondrial enzyme activity
Measured via enzyme activity assays
Time frame
Before and after 2 weeks of exercise training3
Skeletal muscle capillarization
Measured via immunofluorescence
Time frame
Before and after 2 weeks of exercise training4
Skeletal muscle lipid content
Measured via immunofluorescence
Time frame
Before and after 2 weeks of exercise trainingSponsors and contacts
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Source ClinicalTrials.gov