About this trial
The goal of this research is to investigate genetic and environmental factors that contribute to obesity through brain inflammation. The main questions are 1) if identical twins, who differ in food consumption habits, have differences in adiposity markers and brain inflammation and 2) if signs of brain inflammation in response to a specific diet is modified by genetics.
Eligibility criteria
Qualifiers
Age 20-45 years
Differs in habitual diet from co-twin (study 1).
Willing to undergo 7-day overfeeding and hypocaloric feeding periods (study 2)
Member of the Washington State Twin Registry
Disqualifiers
History of bariatric surgery or active participation in weight-loss program
Major medical or neurological disorder (e.g., diabetes, multiple sclerosis)
Known gallbladder disease, anemia, impaired thyroid, kidney or liver function or hypertriglyceridemia (>350 mg/dl) (study 2)
Current use of weight-loss medications or other medications known to alter appetite (e.g., atypical anti-psychotics)
Trial design
Treatments tested in this trial
- Diet modification
Treatment groups
Sponsors and collaborators
University of Washington
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator