This study aims to clinically and radiographically evaluate the adjunctive effect of injectable platelet-rich fibrin (i-PRF) used in combination with a minimally invasive non-surgical technique for the regenerative treatment of intrabony periodontal defects.
Patients of both genders >18 years old, medically free of systemic diseases affecting periodontal regeneration.
Diagnosis of 'periodontitis' stage III (grades B or C).
Single-rooted and multi-rooted vital teeth in either the maxilla or the mandible.
Presence of comparable bilateral two- or three-walled intrabony defects [probing pocket depth (PPD), > 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph] not in a furcation-involved tooth.
Patients with systemic illness known to affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc.
Pregnant and lactating women
Current use of any form of tobacco.
Non-surgical periodontal treatment in the past 6 months, or surgical periodontal treatment in the past 12 months.