The present study has the following objectives:
1. To investigate the prevalence of INOCA in patients referring for a clinically indicated coronary angiography (CA) c/o Division of Cardiology - Federico II University Hospital; 2. To stratify in INOCA endotypes patients according to the presence or absence of alternative (i.e. non obstructive CAD) causes of myocardial ischemia detected during CA clinically indicated through physiology tests; 3. to implement a stratified therapy in these patients considering the different INOCA endotypes and evaluate the impact on angina class and quality of life as well as cardiac hospitalization and coronary revascularization during 5 year follow up
Clinical presentation of chronic ischemic heart dis- ease (IHD), requiring coronary angiography for the diagnosis;
Absence of obstructive coronary artery disease (CAD) at coronary angiography;
Age > 18 years.
Ability to provide a valid informed consent to the study procedure at the time of baseline evaluation;
Presence of obstructive CAD with at least 1 significant coronary artery stenosis, defined as diameterstenosis >50% and FFR ≤0.80 (or iFR/RFR ≤0.89);
Previous coronary artery bypass grafting (CABG);
Left ventricular systolic dysfunction, defined as ejection fraction (EF) <40%;
Severe valvular heart disease;