This is an observational study that will explore the hypothesis that by combining data from patients with liver disease with novel blood biomarkers, single nucleotide polymorphism (SNP) analysis and faecal microbiome analysis. The Investigators will improve diagnosis of liver fibrosis compared to the current available diagnostic tools.
All patients referred to Community Liver Assessment Clinic.
Male or female > 18 years of age.
Females will be non-pregnant and non-lactating.
Age < 18 years.
Pregnancy/breast-feeding. Women of childbearing potential (not >2 years post- menopausal and/or not surgically sterilised) must have a negative blood serum pregnancy test.
Isolated bilirubinaemia.
Known pre-existing liver disease.
Manchester University NHS Foundation Trust
Lead sponsor
University of Manchester
Collaborator
University of Nottingham
Collaborator
Innovate UK
Collaborator