This observational study aims to investigate the characteristics of gut microbiota and their associations with immune and nutritional indicators in children with different respiratory health statuses. A total of 120 children will be enrolled and categorized into four groups: children with Mycoplasma pneumoniae pneumonia (MPP), children with acute respiratory tract infections without Mycoplasma pneumoniae (NMP), children with recurrent respiratory tract infections (RRTIs), and healthy controls. By comparing gut microbiota composition and diversity, as well as immune- and nutrition-related indicators across groups, this study seeks to clarify the potential role of intestinal dysbiosis and host immune-nutritional interactions in the pathogenesis and clinical manifestations of pediatric respiratory tract infections.
Aged 3-14 years;
Good compliance and complete clinical data;
Guardians are informed and sign written consent;
MPP group: meets diagnostic criteria of Guidelines for Diagnosis and Treatment of Mycoplasma Pneumoniae Pneumonia in Children (2023 Edition);
Other infectious diseases (e.g., measles, pertussis, tuberculosis);
Congenital heart disease, immunodeficiency, or major organ dysfunction;
Use of antibiotics, probiotics, immunomodulators, hormones, or microecological preparations within the past 15-30 days;
Unqualified biological samples or incomplete laboratory data.
Min-Tze LIONG
Lead sponsor
Universiti Sains Malaysia
Sponsor institution
940 Hospital of the People's Liberation Army Joint Logistic Support Force
Collaborator