This study is a multicentre, ambidirectional, observational cohort study. The ambidirectional design incorporates both the collection of retrospective data from the three years prior to enrolment, and a prospective follow-up period of up to two years. The study is designed to evaluate the long-term effects of Integrated Medicine on radiographic progression in patients diagnosed with Ankylosing spondylitis (AS).
fulfill the 1984 modified New York criteria for ankylosing spondylitis or the 2009 Assessment of SpondyloArthritis International Society (ASAS) classification criteria for axial spondyloarthritis
age between 18 and 75 years
sign informed consent.
diagnosis of other autoimmune diseases besides the disease under investigation (e.g., rheumatoid arthritis, Sjögren's syndrome, erythema nodosum, myositis, etc.)
pregnancy or lactation
comorbid severe cardiovascular or cerebrovascular diseases, hepatic or renal failure, or malignancy
spondyloarthritis related to enteropathic arthritis, psoriatic arthritis, or reactive arthritis
China-Japan Friendship Hospital
Lead sponsor
The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine
Collaborator
Guangxi Ruikang Hospital
Collaborator
The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
Collaborator
Beijing Electric Power Hospital
Collaborator
Hunan University of Traditional Chinese Medicine
Collaborator
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
Collaborator
Xi'an Fifth Hospital
Collaborator
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Collaborator
Shanghai University of Traditional Chinese Medicine
Collaborator
Shunyi Hospital, Beijing Traditional Chinese Medicine Hospital
Collaborator