Interactive Effects of Sodium and Potassium on Vascular Health in Older Adults
ConditionHealthy Older Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55-75
SponsorFlorida State University
About this trial
The goal of this clinical trial is to determine if a high potassium intake can counteract the harmful effects of excess sodium on endothelial function in older adults with no history of cardiometabolic disease. The main questions it aims to answer are:
1. Can a high potassium intake attenuate dietary sodium-induced endothelial dysfunction in older adults. 2. Do changes in endothelial function in response to alterations in sodium and potassium intake differ by sex.
Participants will participants will consume three controlled diets for 10 days each with a minimum 14-day washout between interventions. The order in which participants consume the diets will be randomized. The study diets will vary in sodium and potassium content. Measures of cardiovascular health (blood pressure, arterial stiffness, endothelial function) will be assessed at the end of each diet.
Eligibility criteria
Qualifiers
Adults ages 55-75 years
At least one-year post-menopause (females)
Willing and able to attend laboratory visits
Disqualifiers
BMI ≥35 kg/m2
Seated blood pressure >135/85 mmHg
Current diagnosis or history of cardiovascular disease, diabetes, renal disease, cancer, or major cardiovascular event (e.g. heart attack or stroke)
Taking exogenous hormones or hormone replacement therapy
Trial design
Treatments tested in this trial
- low sodium/low potassium diet
- high sodium/low potassium diet
- high sodium/high potassium diet
Treatment groups
30 Participants
are divided into 6 treatment groups6
Treatment groupsSee each treatment group below.
Sponsors and collaborators
Florida State University
Lead sponsor
University of Florida
Collaborator
Source ClinicalTrials.gov