Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity Hospital, Strasbourg, France
About this trial
Internuclear ophthalmoplegia is a symptom frequently associated with multiple sclerosis (MS), although other etiologies are possible. Some patients do not meet the diagnostic criteria for MS at the time of the internuclear ophthalmoplegia episode but subsequently convert to MS. Studying this specific clinical situation may help enable earlier diagnosis of MS.
The objective is to analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis and to identify factors associated with this conversion.
The study hypothesis is that the presence of internuclear ophthalmoplegia is highly suggestive of multiple sclerosis, particularly when cerebrospinal fluid-specific oligoclonal bands are present.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients with internuclear ophthalmoplegia listed as a primary or associated diagnosis
Patients hospitalized in a neurology department
Disqualifiers
None
Trial population
The extraction of records will be performed through a search using PMSI coding within the medical files of patients hospitalized in a neurology department.
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
200 Participants
are grouped into 1 trial groupGroup A: Internuclear ophthalmoplegia
Trial outcomes
Primary outcomes
1
Analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis.
Proportion of patients with isolated internuclear ophthalmoplegia who converted to multiple sclerosis during follow-up.
Time frame
1 yearSponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: