Interventions for Clinical High Risk Youth in Tunisia

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age14-28
SponsorUniversity of California, Los Angeles

About this trial

Study participants will take part in one of the two types of treatments aimed at improving daily functioning as follows: either a Cognitive Training (CT) Program or an Enhanced - Treatment as Usual (E-TAU) Group. All group treatments will be provided at Razi Hospital and one of the sessions will be conducted at home. The Cognitive (thinking skills) Training and Neuropsychological Education Approach to Remediation (CT-NEAR) is a form of cognitive (thinking skills) training that consists of computer-game like brain exercises, learning about thinking skills strategies, and a "bridging group" to help participants use what is learned in daily life. Cognitive exercises are generally fun and playful and are done on a computer. The aim is to train thinking skills and ability to function better in daily life such as at school, university, or at work, or with friends and family. The program lasts 12 weeks with two weekly sessions in groups of 3 to 4 participants. Each session is 1½ hours in length and one of the sessions is which lasts 30 minutes is conducted at home using a tablet that will be provided by the study investigators.

Eligibility criteria

Qualifiers

Meets Comprehensive Assessment for At Risk Mental States (CAARMS) criteria for Clinical High Risk

If under the age of 18, the subject has a parent or guardian who can sign consent forms

Premorbid Intelligence Quotient not less than 70

Sufficient fluency in Arabic, French, or English to avoid invalidating research measures

Disqualifiers

Evidence of known neurological disorder, e.g. epilepsy or significant head injury that could account for the CHR symptoms

Evidence of significant and habitual alcohol or substance use in the 6 months prior to study entry

Evidence that the clinical high-risk symptoms were substance-induced

Trial design

Treatments tested in this trial

  • Cognitive training (CT) plus the neuropsychological educational approach to cognitive remediation (NEAR) model and an Enhanced - Treatment as Usual (E-TAU)
  • Enhanced - Treatment as Usual

Treatment groups

54 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University of California, Los Angeles

Lead sponsor

National Institute of Mental Health (NIMH)

Collaborator