IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting (ICARUS)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Hospital, Basel, Switzerland
About this trial
The goal of this international, multi-center, randomized clinical trial is to compare two treatment options, early intracranial stenting and continued stent-retriever or aspiration based endovascular treatment, for stroke patients with a large vessel occlusion, who experienced failure of recanalisation after initial treatment due to intracranial atherosclerosis.
Eligibility criteria
Qualifiers
A relevant clinical deficit defined as a National Institute of Health Stoke Scale (NIHSS) Score of ≥ 6 points for anterior circulation stroke and a NIHSS Score of ≥ 10 for posterior circulation stroke
Anticipated randomization within 24 hours of last seen well (LSW)
Occlusion of the Internal Carotid Artery, the M1 segment, the proximal/dominant M2 segment of the Middle Cerebral Artery, the Basilar Artery or the V4 segment of the Vertebral Artery
Absence of recanalization (thrombolysis in myocardial infarction score of 0 or 1) after up to three endovascular treatment passes
Disqualifiers
Acute intracranial haemorrhage
Pre-stroke modified Rankin Scale score of 3 or above
Known, severe comorbidities, which will likely prevent improvement or follow-up (cancer, alcohol/drug abuse or dementia)
Known clotting disease or suspicion of underlying disease which might lead to a hyper coagulant state
Trial design
Treatments tested in this trial
- Intracranial stenting
- Continuation of conventional endovascular therapy (EVT)
Treatment groups
498 Participants
are divided into 2 treatment groupsSponsors and collaborators
University Hospital, Basel, Switzerland
Lead sponsor
Swiss National Science Foundation
Collaborator
Acandis GmbH
Collaborator
Phenox GmbH
Collaborator
Source ClinicalTrials.gov