Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries

ConditionsIntraoperative Infusion Lidocaine Dexmedetomidine Cerebral Oxygen Saturation Postoperative Delirium Elderly Patients Abdominal Surgeries

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age65+

SponsorTanta University

About this trial

This study aims to compare the effect of intraoperative infusion of either lidocaine or dexmedetomidine on the incidence of postoperative delirium (POD) in elderly patients undergoing major surgeries. It also aims to evaluate the impact of both medications on intraoperative regional cerebral oxygen saturation (rSO₂).

Eligibility criteria

Qualifiers

Age ≥ 65years old.

Both sexes.

Physical status classification of II - III according to the American Society of Anesthesiologists (ASA).

Undergo elective non-cardiac surgeries.

Disqualifiers

History of mental illness, neurological illness, or scoring less than 8 using the abbreviated mental test (AMT) before operation.

Severe hearing or visual impairment that may interfere with communication.

Severe renal or hepatic dysfunction.

Patients on central nervous system (CNS) medications (antipsychotics, anticonvulsants, antiparkinsonian, antidepressants).

Trial design

Treatments tested in this trial

Lidocaine
Dexmedetomidine

Treatment groups

100 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Tanta University

Lead sponsor

Source ClinicalTrials.gov