About this trial
STEMI represents the subtype of ACS with the worst prognosis, associated with high mortality and an elevated risk of complications. The use of IVI guidance holds the potential to reduce the incidence of MACE. In previous studies, there has been limited research on intravascular imaging in the context of primary revascularization procedures for STEMI, and no large-scale cohort study has compared the differences in clinical outcomes between IVI-guided and angiography-guided primary revascularization. Therefore, we conducted this large-scale randomized controlled trial to compare IVI-guided primary PCI versus coronary angiography-guided primary PCI in patients with STEMI.
Eligibility criteria
Qualifiers
Patients diagnosed with acute ST-segment elevation myocardial infarction (STEMI) who have an indication for emergency interventional therapy;
Subjects who are eligible to undergo primary percutaneous coronary intervention (PCI);
Subjects or their authorized family members voluntarily agree to participate in the clinical trial and sign the written informed consent form;
The IVUS catheter is expected to pass through the target lesion to complete the examination.
Disqualifiers
Patients with cardiogenic shock or severe heart failure (Killip class IV);
Patients who have previously undergone coronary artery bypass grafting (CABG);
Patients with coma or disturbance of consciousness;
Patients who are expected to be intolerant to long-term antiplatelet therapy;
Trial design
Treatments tested in this trial
- Intravascular Ultrasound
- Coronary angiography guidance
Treatment groups
Sponsors and collaborators
Shanghai Zhongshan Hospital
Lead sponsor
Shanghai 10th People's Hospital
Collaborator