Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorUniversity of Minnesota
About this trial
The goal of this study is to learn more about the brain pathways and activity involved in creating Visual Snow Syndrome (VSS). The main questions it aims to answer are:
* Does VSS arise from spontaneous activity in brain pathways? * Where in the brain does the activity contributing to VSS arise? * How does brain activity contribute to VSS?
Participants will:
1. Undergo assessments and questionnaires to understand visual and mental symptoms, cognitive, and sensory function. 2. Make visual judgements based on images presented to them both inside and outside a magnetic resonance imaging (MRI) machine. 3. Undergo scanning of their brain while inside of an MRI machine.
Eligibility criteria
Qualifiers
Between the ages of 18 and 60 years old
Normal (20/25 or better in each eye) or corrected-to-normal vision (MR-compatible glasses will be provided as needed)
Ability to comply with study instructions
Individuals who have a current diagnosis of VSS from a neuro-ophthalmologist or meet diagnostic criteria of VSS (experience of dynamic dots across the visual field persisting longer than 3 months and at least 2 of the following additional visual symptoms: palinopsia, entoptic phenomena, trails behind moving objects, photophobia, or nyctalopia)
Disqualifiers
Not being fluent in English or another language for which interpretation/translation services are available
A diagnosed or self-reported intellectual disability
Current substance dependence (besides nicotine), or drug dependence with tolerance or withdrawal within past 12 months
Hallucinogenic substance use within the past 12 months or hallucinogenic substance use within 12 months prior to onset of VSS symptoms
Trial design
Treatments tested in this trial
- Visual Adaptation
- Assessments and Questionnaires
- Functional Magnetic Resonance Imaging (fMRI)
- Magnetic Resonance Imaging (MRS)
Treatment groups
100 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Minnesota
Lead sponsor
National Institutes of Health (NIH)
Collaborator
Mayo Clinic
Collaborator
National Eye Institute (NEI)
Collaborator
Source ClinicalTrials.gov