This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health in middle-aged adults (50-65 years old). The hypothesis is that (1) each intervention alone (IHT or PA) provides cognitive benefits and (2) combining IHT with PA may yield additive or synergistic effects, particularly when administered simultaneously rather than sequentially. By comparing these distinct interventions, the study aims to determine which approach best preserves or enhances cognitive performance in middle-aged adults. Findings from this research may inform non-pharmacological strategies to promote healthy aging and reduce the risk of age-related cognitive decline.
Adults aged 50 to 65 years (male and female)
Montreal Cognitive Assessment (MoCA) score ≥ 24
No participation in any structured exercise intervention in the last 6 months
No exposure to altitudes above 1,500 m in the preceding 3 months
Active smoking
Major cardiovascular complications within the last 3 months (e.g., myocardial i-infarction, unstable angina, severe arrhythmias)
Severe hypertension (≥180 mmHg systolic or ≥110 mmHg diastolic)
Chronic respiratory insufficiency (e.g., COPD, sleep apnea)
Ayoub Boulares
Lead sponsor
University of Poitiers
Sponsor institution
University of Poitiers
Collaborator
Laboratory MOVE, Faculty of Sport Sciences, University of Poitiers, France
Collaborator