Investigating the Plasticity of Human Predictive Coding Through Neuromodulation

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorUniversità Vita-Salute San Raffaele

About this trial

The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.

Eligibility criteria

Qualifiers

Participant is willing and able to give informed consent for participation in the study.

Aged 18-35 years.

Normal or corrected to normal vision, as per anamnestic investigation.

Disqualifiers

Participants with a diagnosis of epilepsy (as per anamnestic investigation).

Participants with major neurological disorders (as per anamnestic investigation).

Participants that are currently under psychopharmacological treatment with tricyclic antidepressants (as per anamnestic investigation).

Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants (as per anamnestic investigation).

Trial design

Treatments tested in this trial

  • Occipital tACS at IAF-2Hz
  • Occipital tACS at IAF+2Hz
  • Frontal tACS at 4-7 Hz
  • Occipital tRNS
  • Frontal tRNS
  • Sham/placebo tACS
  • Sham/placebo tRNS

Treatment groups

210 Participants
are divided into 7 treatment groups

7

Treatment groups

See each treatment group below.

Sponsors and collaborators

Università Vita-Salute San Raffaele

Lead sponsor

Alessia Santoni

Collaborator

Sara Stottmeier

Collaborator

Klara Hemmerich

Collaborator

Giuseppe Di Dona

Collaborator

Luigi Ferini-Strambi

Collaborator