Health TrialsbyHealthPanel

Investigating the Plasticity of Human Predictive Coding Through Neuromodulation

ConditionHuman Brain and Cognition
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorUniversità Vita-Salute San Raffaele

About this trial

The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Participant is willing and able to give informed consent for participation in the study.

Aged 18-35 years.

Normal or corrected to normal vision, as per anamnestic investigation.

Disqualifiers

Participants with a diagnosis of epilepsy (as per anamnestic investigation).

Participants with major neurological disorders (as per anamnestic investigation).

Participants that are currently under psychopharmacological treatment with tricyclic antidepressants (as per anamnestic investigation).

Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants (as per anamnestic investigation).

Trial design

Design model

Parallel

Treatments tested in this trial

  • Occipital tACS at IAF-2Hz

    Procedure/Surgery

    tACS applied to occipital areas at 2 Hz below the individual alpha frequency (IAF)

  • Occipital tACS at IAF+2Hz

    Procedure/Surgery

    tACS applied to occipital areas at 2 Hz above the individual alpha frequency (IAF)

  • Frontal tACS at 4-7 Hz

    Procedure/Surgery

    tACS applied to frontal areas at 4-7 Hz

  • Occipital tRNS

    Procedure/Surgery

    tRNS applied to occipital brain regions

  • Frontal tRNS

    Procedure/Surgery

    tRNS applied to frontal brain regions

  • Sham/placebo tACS

    Procedure/Surgery

    tACS is activated only for 30 seconds and then turned off, thus resulting ineffective

  • Sham/placebo tRNS

    Procedure/Surgery

    tRNS is activated only for 30 seconds and then turned off, thus resulting ineffective

Treatment groups

210 Participants
are divided into 7 treatment groups

7

Treatment groups

See each treatment group below.

Group A: Occipital tACS at IAF-2HzExperimental treatment 1 intervention
Group B: Occipital tACS at IAF+2HzExperimental treatment 1 intervention
Group C: Frontal tACS at 4-7 HzExperimental treatment 1 intervention
Group D: Sham/placebo tACSSham comparator 1 intervention
Group E: Occipital tRNSExperimental treatment 1 intervention
Group F: Frontal tRNSExperimental treatment 1 intervention
Group G: Sham/placebo tRNSSham comparator 1 intervention

Trial outcomes

Primary outcomes

1

Behavioral measures

To study if tACS or tRNS delivered in different brain networks can modulate the learning of statistical regularities in the context of visual perception we will evaluate the following behavioral measures recorded in a computerized visual perception task: hit rate, miss, false alarms, correct rejections. These behavioral measures will allow to derive measures of sensitivity (d') and response criterion (Beta and C), according to the theoretical framework of the Signal Detection Theory (SDT).

Time frame
During the procedure

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Università Vita-Salute San Raffaele

Lead sponsor

Alessia Santoni

Collaborator

Sara Stottmeier

Collaborator

Klara Hemmerich

Collaborator

Giuseppe Di Dona

Collaborator

Luigi Ferini-Strambi

Collaborator

Source ClinicalTrials.gov
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