About this trial
The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.
Eligibility criteria
Qualifiers
Participant is willing and able to give informed consent for participation in the study.
Aged 18-35 years.
Normal or corrected to normal vision, as per anamnestic investigation.
Disqualifiers
Participants with a diagnosis of epilepsy (as per anamnestic investigation).
Participants with major neurological disorders (as per anamnestic investigation).
Participants that are currently under psychopharmacological treatment with tricyclic antidepressants (as per anamnestic investigation).
Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants (as per anamnestic investigation).
Trial design
Treatments tested in this trial
- Occipital tACS at IAF-2Hz
- Occipital tACS at IAF+2Hz
- Frontal tACS at 4-7 Hz
- Occipital tRNS
- Frontal tRNS
- Sham/placebo tACS
- Sham/placebo tRNS
Treatment groups
7
Treatment groupsSee each treatment group below.
Sponsors and collaborators
Università Vita-Salute San Raffaele
Lead sponsor
Alessia Santoni
Collaborator
Sara Stottmeier
Collaborator
Klara Hemmerich
Collaborator
Giuseppe Di Dona
Collaborator
Luigi Ferini-Strambi
Collaborator