About this trial
The goal of this observational case-control study is to evaluate the relationship between temporal bone computed tomography (CT) findings, bone mineral density (BMD), and audiological parameters in adults diagnosed with otosclerosis. The main questions it aims to answer are:
Is there a correlation between temporal bone CT density values and the severity of hearing loss in otosclerosis? Do bone mineral density and serum vitamin D levels differ between otosclerosis patients and individuals without otosclerosis? Researchers will compare patients diagnosed with otosclerosis to a control group without otosclerosis to determine if CT-based density variations are associated with disease severity and systemic bone metabolism markers.
Participants who have already had a temporal bone CT scan as part of their routine clinical evaluation will undergo:
Bone mineral density (BMD) assessment via dual-energy X-ray absorptiometry (DEXA) Serum vitamin D level measurement Audiological testing, including pure tone audiometry and speech discrimination tests This study aims to improve the diagnostic and prognostic understanding of otosclerosis by integrating imaging, metabolic, and audiological data.
Eligibility criteria
Qualifiers
Adults diagnosed with otosclerosis based on audiological and clinical assessment
Patients with available high-resolution CT scans and audiological data
Individuals who have undergone stapedectomy or stapedotomy surgery
Availability of bone mineral density and serum vitamin D data
Disqualifiers
History of primary metabolic bone diseases (osteoporosis, Paget's disease)
Use of medications affecting bone metabolism (bisphosphonates, corticosteroids)
History of chronic otitis media or prior ear surgeries
Patients who received head and neck radiotherapy
Trial design
Treatments tested in this trial
- Not listed
Trial groups
Sponsors and collaborators
İbrahim Emir Yeşil
Lead sponsor
Hacettepe University
Sponsor institution