Involvement of Archaea in Carious Disease
ConditionDental Caries
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAssistance Publique Hopitaux De Marseille
About this trial
Dental caries is a major public health probleme the result of hard tissue demineralization and oral microbiota changes.
Methanogenic archaea, mainly Methanobrevibacter oralis, are associated with various oral problems, including pathologies periodontal.
Previous research has not really studied the Archaea in carious lesions, hence the importance of our study.
Our study aims to explore their potential role in the the development of caries by analysing their prevalence and their quantification in relation to the carious risk individual. The aim is to improve understanding of the Cavity microbiology to advance management of this pathology in terms of prevention or of treatment.
Our team is particularly competent in the field of Archaea, especially in the cultivation of Archaea methanogens since we have a dedicated platform. We also discovered the first human Nanoarchaea, opening up a whole new possible search field.
Eligibility criteria
Qualifiers
Male or female of legal age.
Patient who is a beneficiary or entitled beneficiary of a social security
Patient under the care of the Restorative and Preventive Dentistry of the PROMOD - Timone Dentistry Unit.
Patients capable of giving written consent.
Disqualifiers
None
Trial design
Treatments tested in this trial
- saliva sample
- carious tissue samples
Treatment groups
200 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov