Purpose of this study is to compare the efficacy of intravenous and intraosseous antibiotic administration techniques during revision total knee arthroplasty
Patient is undergoing a revision total knee arthroplasty where in the opinion of the investigator, the patient's existing tibial component excludes the tibial tubercle as a valid intraosseous injection site.
Patient is able to understand the study design and intervention and gives informed consent to participate in the study.
Age > 18 years.
Contraindication to receiving vancomycin, cefepime, ancef, or other standard of care pre-operative antibiotic (allergy, medical issue, etc).
Patient received or is scheduled to receive intravenous Vancomycin within 7 days prior to their planned revision procedure.
Any hardware, condition, or anatomic status that prevents the medial malleolus from being a viable intraosseous injection site.
Refusal to participate