Iron Absorption and Losses in Young South African Women Living Without and With Overweight and Obesity
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-35
SponsorLinda Malan
About this trial
Young women living with obesity (OB) have a greater risk of developing iron deficiency. Plus, the risk of anemia and/or ID in young women living with overweight (OW) and obesity (OB) is further increased by inadequate dietary intake and/or poor bioavailability of iron, as well as gastrointestinal and menstrual iron losses. It is not certain whether women living with OW/OB can meet their iron requirements from their day-to-day diet.
The aim of this study is to compare iron absorption and losses over a long period between women living with and without OW and OB. Secondary outcomes include iron and inflammation status, as well as dietary iron intake.
Eligibility criteria
Qualifiers
Of African descent
BMI of 18.5 to 24.9 kg/m2 for participants living without OW/OB and BMI ≥ 28 kg/m2 for participants living with OW/OB
Having low to moderate inflammation-adjusted iron stores (ferritin ≤50 µg/L)
Absence of low-grade inflammation (CRP<2 mg/l) for participants living without OW/OB and presence of low-grade inflammation CRP 2-20 mg/l) for participants living with OW/OB
Disqualifiers
Hemoglobin < 11 g/dl
Treated or self-reported chronic or malabsorptive disorder
Current use of chronic anti-inflammatory medication, like corticosteroids or non-steroidal anti-inflammatory medication
Pregnancy or planning to become pregnant in the next 2 years
Trial design
Treatments tested in this trial
- Ferrous sulfate
Treatment groups
70 Participants
are divided into 2 treatment groupsSponsors and collaborators
Linda Malan
Lead sponsor
North-West University, South Africa
Sponsor institution
King's College London
Collaborator
ETH Zurich (Switzerland)
Collaborator
Source ClinicalTrials.gov