Ischaemic Lesions in Acute Intracerebral Haemorrhage
ConditionIntracerebral Haemorrhage
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-120
SponsorUniversity of Leicester
About this trial
The aim of this observational study is to determine how and why inadequate brain blood flow occurs after bleeding in patients with intracerebral haemorrhage (ICH). Treatment for strokes caused by burst blood vessels involves reducing blood pressure (BP) to stop the bleeding. However, this reduction in BP may affect blood flow, causing blockages in blood vessels within the brain. Fast breathing also affects brain blood flow. Therefore, participants will be asked to undergo a simple brain blood flow assessment using transcranial Doppler (TCD) within 48 hours upon admission to hospital. Patients will then have a follow-up TCD assessment at 4-7 days post-ICH onset, in addition to an MRI scan at \>7 days. This research will help to confirm if blockages after bleeding are caused by reduced blood flow within the brain.
Eligibility criteria
Qualifiers
Clinical diagnosis of a haemorrhagic stroke on CT imaging within 48 hours of onset (for patients waking with a stroke, time of onset will be taken to be the time when the patient was last asymptomatic).
Male or female, aged 18 years or above.
Disqualifiers
MRI imaging is contraindicated or unlikely to tolerate scanning process due to clinical instability (GCS <8, unable to lie supine).
Patients requiring anaesthesia.
Male or Female, aged under 18 years.
Clinical diagnosis of stroke greater than 48 hours from onset
Trial design
Treatments tested in this trial
- Transcranial Doppler ultrasonography (TCD)
Treatment groups
120 Participants
are divided into 1 treatment groupSponsors and collaborators
University of Leicester
Lead sponsor
University Hospitals, Leicester
Collaborator
Source ClinicalTrials.gov