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Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass

ConditionsCoronary Artery Disease (CAD)Left Ventricular (LV) Systolic DysfunctionInduction AnesthesiaCoronary Bypass Graft SurgeryKetamineFentanylLidocaine
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21+
SponsorCairo University

About this trial

This study compares ketamine/fentanyl versus ketamine/lidocaine in term of their impact on cerebral perfusion during CABG. No prior data address these effects, and the goal is to identify the induction regimen that better preserves cerebral oxygenation.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

patients with coronary artery disease

with moderate to severe left ventricular dysfunction (ejection fraction < 40%),

scheduled for elective CABG surgery

Disqualifiers

associated chronic stroke, TIA , carotid occlusive disease( due to abnormal vasomotor activity), patients with known neurological impairment (cerebral infarction , dementia ), significant carotid artery stenosis ,

valvular heart disease,

persistent arrhythmias,

congestive cardiac failure,

Trial design

Design model

Parallel

Treatments tested in this trial

  • Fentanyl (IV)

    Drug

    patients will receive 1 mcg/kg of Fentanyl (10 mcg/mL).

  • lidocaine

    Drug

    patients will receive 1 mg/kg lidocaine (10mg/mL)

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: fentanyl groupActive comparator 1 intervention
Group B: lidocaine groupActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

average postinduction NIRS

average values of NIRS reading after induction of anesthesia

Time frame
every 5 min after induction of anesthesia until 20 min after

Secondary outcomes

1

mean arterial pressure

invasive mean arterial pressure

Time frame
every minute after induction of anesthesia until 20 min after induction
2

heart rate

bpm

Time frame
every minute after induction of anesthesia until 20 min after induction
3

NRIS

average of left and right side reading

Time frame
during induction, 1 min after induction, during intubation, then every 5 minutes for 20 min
4

cerebral hypoperfusion

NIRS\<60% or \<90% of baseline reading

Time frame
during induction, 1 min after induction, during intubation, then every 5 minutes for 20 min

Other outcomes

1

vasopressor dose

Time frame
immediately after induction until 20 min after induction

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov
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