Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass

ConditionsCoronary Artery Disease (CAD)Left Ventricular (LV) Systolic Dysfunction Induction Anesthesia Coronary Bypass Graft Surgery Ketamine Fentanyl Lidocaine

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age21+

SponsorCairo University

About this trial

This study compares ketamine/fentanyl versus ketamine/lidocaine in term of their impact on cerebral perfusion during CABG. No prior data address these effects, and the goal is to identify the induction regimen that better preserves cerebral oxygenation.

Eligibility criteria

Qualifiers

patients with coronary artery disease

with moderate to severe left ventricular dysfunction (ejection fraction < 40%),

scheduled for elective CABG surgery

Disqualifiers

associated chronic stroke, TIA , carotid occlusive disease( due to abnormal vasomotor activity), patients with known neurological impairment (cerebral infarction , dementia ), significant carotid artery stenosis ,

valvular heart disease,

persistent arrhythmias,

congestive cardiac failure,

Trial design

Treatments tested in this trial

Fentanyl (IV)
lidocaine

Treatment groups

40 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Cairo University

Lead sponsor

Source ClinicalTrials.gov