Knee Arthroplasty Recovery With Transcranial Direct Current Stimulation
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorWomen's College Hospital
About this trial
Total knee arthroplasty (TKA) is widely performed to reduce pain from advanced osteoarthritis, yet many patients experience severe postoperative pain and up to 25-44% develop chronic postsurgical pain (CPSP). Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has shown promise in reducing pain and opioid use in early studies but has not been evaluated using comprehensive perioperative, home-based protocols. This study will test whether a home-based tDCS intervention delivered before and after TKA can improve acute pain management and reduce the development of CPSP.
Eligibility criteria
Qualifiers
18 years of age or older.
American Society of Anesthesiologists (ASA) Physical Classification Status I-III.
Scheduled to undergo unilateral elective primary total knee arthroplasty for advanced osteoarthritis of the knee.
Access to a device running iOS Version 10.0 or above, or Android Version 5.0 or above that can connect to the internet.
Disqualifiers
History of brain surgery, central nervous system tumors, seizures (including epilepsy), stroke or intracranial implants (e.g plates, screws, deep brain stimulators)
Have vascular, traumatic, infectious, or metabolic lesions or diseases of the brain
Insomnia disorder (e.g., difficulty initiating or maintaining sleep, early morning awakening)
Obstructive sleep apnea (OSA)
Trial design
Treatments tested in this trial
- Active tDCS Stimulation
- Sham tDCS Stimulation
Treatment groups
70 Participants
are divided into 2 treatment groupsSponsors and collaborators
Women's College Hospital
Lead sponsor
AFP Innovation Fund
Collaborator
University Health Network, Toronto
Collaborator
Source ClinicalTrials.gov