About this trial
This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods.
The study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail.
The hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.
Eligibility criteria
Qualifiers
Aged 40-70 years
Radiographically confirmed knee OA (Kellgren-Lawrence [KL] Grade 2 or 3)
Able to walk independently (assistive devices permitted)
Aged 40-70 years
Disqualifiers
Uncontrolled hypertension or other cardiovascular disease
A musculoskeletal condition preventing physical testing
Neurological muscle weakness (e.g., stroke, spinal cord injury)
BMI >34.9 kg/m²
Trial design
Treatments tested in this trial
- Eccentric resistance training
Treatment groups
Sponsors and collaborators
University of Colorado, Denver
Lead sponsor
NIH/NCATS Colorado CTSA Grant Number T32TR004367
Collaborator