Lactated Ringer's Solution to Prevent Post-ERCP Pancreatitis

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-74
SponsorUniversity of South Florida

About this trial

This is a randomized, double-blinded, controlled trial. This study is a head to head comparison of normal saline (NS) infusion versus Lactated Ringer's (LR) infusion in patients, with the primary outcome of post-ERCP pancreatitis occurrence. Patients will be randomized to either the NS infusion group or the LR infusion group. IVF will be started pre-procedurally and will be continued throughout the procedure. A IVF bolus will be given at the end of the procedure and then continued as a continuous infusion. Our null hypothesis is that there will be no significant difference in the rate of occurrence of post-ERCP pancreatitis between the infusion of LR and NS solutions. Our alternative hypothesis is that patients receiving LR solution infusion will experience a decreased rate of post-ERCP pancreatitis compared to patients receiving NS solution infusion.

Eligibility criteria

Qualifiers

Suspicion of Oddi dysfunction

Personal history of post-ERCP pancreatitis

More than 8 cannulation attempts

Precut sphincterotomy

Disqualifiers

Patients aged less than 18

Inability to provide informed consent

Pregnancy

Active acute pancreatitis

Trial design

Treatments tested in this trial

  • Lactated Ringer
  • Normal Saline 0.9% Infusion Solution Bag

Treatment groups

242 Participants
are divided into 2 treatment groups

Locations

This trial has no locations

Sponsors and collaborators