About this trial
This is a randomized, double-blinded, controlled trial. This study is a head to head comparison of normal saline (NS) infusion versus Lactated Ringer's (LR) infusion in patients, with the primary outcome of post-ERCP pancreatitis occurrence. Patients will be randomized to either the NS infusion group or the LR infusion group. IVF will be started pre-procedurally and will be continued throughout the procedure. A IVF bolus will be given at the end of the procedure and then continued as a continuous infusion. Our null hypothesis is that there will be no significant difference in the rate of occurrence of post-ERCP pancreatitis between the infusion of LR and NS solutions. Our alternative hypothesis is that patients receiving LR solution infusion will experience a decreased rate of post-ERCP pancreatitis compared to patients receiving NS solution infusion.
Eligibility criteria
Qualifiers
Suspicion of Oddi dysfunction
Personal history of post-ERCP pancreatitis
More than 8 cannulation attempts
Precut sphincterotomy
Disqualifiers
Patients aged less than 18
Inability to provide informed consent
Pregnancy
Active acute pancreatitis
Trial design
Treatments tested in this trial
- Lactated Ringer
- Normal Saline 0.9% Infusion Solution Bag