Language, Speech and Motor Function in MCI Due to AD and Alzheimer's Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorHanze University of Applied Sciences Groningen
About this trial
The goal of this observational cross-sectional study is to explore the characteristics of language, speech, and motor function in persons with Mild Cognitive Impairment due to Alzheimer's disease ("MCI due to AD") and persons with mild and moderate Alzheimer's disease ("AD"). This study aims to:
* Explore motor, speech, and language functions in MCI due to AD and mild and moderate AD. * Combine the characteristics of motor, language, and speech functions to gain more insight into the association of language, speech, and motor changes during MCI due to AD and mild and moderate AD.
Researchers will compare the outcomes to an age-matched control group without cognitive impairment.
Participants will undergo:
* Two motor function tests to assess gait and hand grip strength. * Four language and speech function tests to assess spontaneous speech and verbal fluency..
Eligibility criteria
Qualifiers
Established diagnosis of MCI due to AD with a likelihood according to NIA-AA criteria (Albert et al., 2011).
A score of stage three on the Global Deterioration Scale (GDS) (Reisberg et al., 1982).
Established diagnosis of AD (amnestic or non-amnestic) or etiologically mixed presentation of AD according to DSM-5 (American Psychiatric Association, 2013) or NINCDS-ARDRA criteria (Jack et al., 2018; McKann et al., 2011).
The following scores on the Global Deterioration Scale (GDS): four for mild AD, five for moderate AD (Reisberg et al., 1982).
Disqualifiers
Having a neurological or neurodegenerative disease or disorder that may be contributing to cognitive impairment above and beyond that caused by AD or mixed AD; Down's syndrome, other subtypes of dementia, autism spectrum disorder.
Having an established diagnosis of a psychiatric disorder, e.g. schizophrenia, depression.
Hearing loss (with or without hearing aid) that affects communication.
Vision loss (with or without glasses or lenses) that affects communication.
Trial design
Treatments tested in this trial
- GAITRite walkway system OR 4-meter walking speed test
- Jamar hand dynamometer
- Picture description task
- Autobiographical semi-structured conversation
- Verbal fluency
Treatment groups
208 Participants
are divided into 4 treatment groupsSponsors and collaborators
Hanze University of Applied Sciences Groningen
Lead sponsor
University of Groningen
Collaborator
Source ClinicalTrials.gov