Large Artery Occlusion Treated in Extended Time With Mechanical Thrombectomy Trial
ConditionAcute Ischemic Stroke
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorFudan University
About this trial
A multi-center, prospective, randomized, open-label, adaptive group sequential designed, blinded endpoint assessment (PROBE) clinical trial of endovascular treatment among selected AIS
Eligibility criteria
Qualifiers
Age ≥18 years
Present 24-72 hours of stroke onset or last seen well
Clinical diagnosis of AIS due to anterior circulation LVO (from internal carotid artery (ICA) extracranial segment to middle cerebral artery (MCA) M1 and M2 segment) on brain imaging
National Institute of Health stroke scale (NIHSS) ≥6 at randomisation
Disqualifiers
Considered unlikely to benefit from trial (e.g. advanced dementia, major pre-stroke disability (prior modified Rankins scale (mRS) ≥2), high likelihood of early death), as judged by the responsible treating clinician
Major co-morbid disease that could interfere with outcome assessments and follow-up (e.g. cancer, severe heart failure, kidney failure)
Pregnancy
Unable to undergo a CTP
Trial design
Treatments tested in this trial
- Mechanical thrombectomy
Treatment groups
336 Participants
are divided into 2 treatment groupsSponsors and collaborators
Fudan University
Lead sponsor
Changhai Hospital
Collaborator
Source ClinicalTrials.gov