Left Bundle Branch Area Pacing or Biventricular Pacing in AF and Left Ventricular Dysfunction
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
Sponsorsrdpiers
About this trial
It is unknown whether left bundle branch area pacing (LBBAP) or biventricular pacing best prevents or reverses left ventricular (LV) adverse remodelling in patients with atrial fibrillation (AF) who require ventricular pacing or CRT. This randomized non-inferiority cross-over trial will compare left ventricular end-systolic volume change and secondary endpoints between LBBAP and biventricular pacing in patients with AF and LV dysfunction.
Eligibility criteria
Qualifiers
Adults ≥18 years with permanent AF and LVEF < 50% who either require ventricular pacing because of bradycardia including patients undergoing AV junction ablation, or have an indication for cardiac resynchronization therapy.
Expected percentage of ventricular pacing > 40%
≥ 3 months of heart failure medication optimization
Disqualifiers
Age < 18 years
Pregnancy or active pregnancy wish
Not eligible for implantation of an RV lead, LBBAP lead, or LV lead in the coronary sinus
Recent valve intervention/surgery or acute myocardial infarction (< 6 months)
Trial design
Treatments tested in this trial
- Left bundle branch area pacing
- Biventricular pacing
Treatment groups
34 Participants
are divided into 2 treatment groupsSponsors and collaborators
srdpiers
Lead sponsor
Leiden University Medical Center
Sponsor institution
Aarhus University Hospital
Collaborator
Source ClinicalTrials.gov