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Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery

ConditionsLidocaineDexmedetomidineInfusionPerioperative PainVideo-Assisted Thoracoscopic Surgery
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAin Shams University

About this trial

This study aims to compare lidocaine and dexmedetomidine infusion and their combination on perioperative pain in patients undergoing video-assisted thoracoscopic surgery.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥18 years old.

Both sexes.

American Society of Anesthesiologists (ASA) physical status of I, II.

Patients undergoing video-assisted thoracoscopic surgery (VATS) under general anesthesia.

Disqualifiers

Hypersensitivity to any of the used drugs.

Coagulation disorder.

Body mass index >35 kg/m2.

History of chronic pain requiring daily opioids/steroids/clonidine/other α2 agonist/analgesics or any drugs acting on the central nervous system during the previous 2 weeks, and drug/alcohol abuse.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Lidocaine

    Drug

    Patients will receive lidocaine 0.3 mg/kg over 10 min loading, 0.3 mg/kg/h infusion after induction of anesthesia as maintenance dose till 10 min before the end of the operation plus saline 0.9% with same rate of dexmedetomidine.

  • Dexmedetomidine

    Drug

    Patients will receive dexmedetomidine 0.5 μg/kg infusion over 10 min as a loading dose then 0.5 μg/kg/h after induction of anesthesia as maintenance dose till 10 min before the end of the operation plus saline 0.9% with same rate of lidocaine.

  • Lidocaine and Dexmedetomidine

    Drug

    Patients will receive lidocaine (0.3 mg/kg in 10 min loading, 0.3 mg/kg/h infusion) and dexmedetomidine infusions (0.5 μg/kg infusion over 10 min as a loading dose then 0.5 μg/kg/h) till 10 min before the end of the operation.

Treatment groups

75 Participants
are divided into 3 treatment groups
Group A: Lidocaine groupExperimental treatment 1 intervention
Group B: Dexmedetomidine groupExperimental treatment 1 intervention
Group C: Lidocaine and Dexmedetomidine groupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Total morphine consumption

Rescue analgesia of morphine will be given as 3 mg bolus if the Visual Analogue Scale (VAS)\> 3 to be repeated after 30 min if pain persists until the VAS \< 4.

Time frame
24 hours postoperatively

Secondary outcomes

1

Time of extubation

Time from the end of surgery till extubation

Time frame
24 hours postoperatively
2

Time to the first request for the rescue analgesia

Time to the first request for the rescue analgesia (time from end of surgery to first dose of morphine administrated).

Time frame
24 hours postoperatively
3

Degree of pain

Each patient will be instructed about postoperative pain assessment with the Visual Analogue Scale (VAS). VAS (0 represents "no pain" while 10 represents "the worst pain imaginable"). VAS will be assessed at 0, 4, 8, 12, 18 and 24h postoperatively.

Time frame
24 hours postoperatively
4

Degree of patient satisfaction

The degree of patient satisfaction will be assessed on a 5-point Likert scale patient satisfaction (1, extremely dissatisfied; 2, unsatisfied; 3, neutral; 4, satisfied; 5, extremely satisfied).

Time frame
24 hours postoperatively

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ain Shams University

Lead sponsor

Source ClinicalTrials.gov
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