The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau protein), physical fitness, and metabolism in older adults at increased risk of developing Alzheimer's disease.
Age 60-80 years
Diagnosis of Subjective Cognitive Impairment (SCI) or Mild Cognitive Impairment (MCI)
mini-mental-scale (MMSE) score between 24-30
Positive plasma pTau217 biomarker
Stroke or myocardial infarction within the past year
Decompensated internal conditions (e.g., severe heart failure, kidney failure, unstable diabetes, GLP1 agonist therapy)
Long-term psychiatric treatment (except well-managed depression)
Neurological conditions affecting mobility or cognition (e.g., Parkinson's disease, severe tremor, epilepsy)
St. Anne's University Hospital Brno, Czech Republic
Lead sponsor
Slovak Academy of Sciences
Collaborator