About this trial
The goal of this randomized controlled two-arm trial is to determine the effect of a diet and exercise intervention for 12 weeks on body composition, muscle function, and energy balance in 80 adults aged 50 years and over with obesity and insulin resistance. The main questions the trial aims to answer are: Will 12 weeks of a structured nutrition plan + exercise reduce fat mass, improve muscle function, and increase energy deficit compared to the usual diet + exercise. The hypothesis is that 12 weeks of a structured nutrition plan + exercise will reduce fat mass, improve muscle function, and produce greater energy deficit than the usual diet + exercise. Participants will be provided with all meals for 12 weeks and will exercise at the Center under supervision three times each week. Pre and post-intervention, body composition, physical function, and energy deficit will be measured.
Eligibility criteria
Qualifiers
Age > 50 years.
Body mass index (BMI) ≥ 30 kg/m2.
Homeostatic model assessment of insulin resistance ≥ 3.
Mini-Mental State Examination (MMSE) > 25.
Disqualifiers
Diagnosis of cancer (received within five years) or diabetes (type 1 and 2), or significant musculoskeletal, or cardiovascular, or hepatic, or renal, disease or dysfunction.
Clinically significant gastrointestinal malabsorption syndromes such as chronic diarrhea, celiac disease, or clinically significant abnormal laboratory markers.
Fluctuation in body weight > 3 kg in the preceding two months
Condition that impedes testing of the study hypothesis or makes it unsafe to exercise or consume the study foods.
Trial design
Treatments tested in this trial
- Structured nutrition plan
- Typical or usual diet
- Supervised Exercise
Treatment groups
Sponsors and collaborators
Pennington Biomedical Research Center
Lead sponsor
National Institute on Aging (NIA)
Collaborator