This study aims to test whether a multi-disciplinary intervention involving exercise and nutrition can slow down the decline in physical function, muscle strength and mass in older adults (aged 65-75) with Type 2 diabetes (T2D) and obesity treated with Semaglutide.
The main questions it aims to answer are:
In older people with T2D and obesity, treated with Semaglutide, does a multi-disciplinary intervention of exercise and nutrition compared to standard health recommendations:
1. Reduce the rate of decline in muscle mass? 2. Reduce the rate of decline in muscle strength? 3. Reduce the rate of decline in physical function?
Participants will:
Administer Semaglutide once weekly for 6 months. Visit the clinic once every 8 weeks for checkups and tests. Keep a diary of their exercise and food consumption. Participants in the intervention group will participate in an online exercise program and will receive personal nutritional counseling.
Patients 65-75 years old.
Patients who were previously diagnosed with type 2 diabetes.
Overweight / obesity (body mass index, BMI ≥ 27 kg/m2).
Patients with significant hearing or visual disability.
Patients with Estimated Glomerular Filtration Rate (eGFR)<30 ml/min/1.73 m2.
Patients who are in active nutritional therapy.
Patients who changed their diet recently (< 1 month) and/or in a weight-loss program with >5% weight loss or used anti-obesity drugs in the last 3 months.
Sheba Medical Center
Lead sponsor
Hadassah Medical Organization
Collaborator