Linked-Color Imaging Versus Indigo Carmine Pump Spraying on the Colorectal Adenoma Detection Rate
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45-85
SponsorShandong University
About this trial
Detection and removal of polyps during colonoscopy is crucial for the prevention of colorectal cancer. Indigo carmine spraying up to the colonic mucosa could probably increase the adenoma detection rate, but considering the long withdrawal time of the endoscope and the resulting increase in time and cost. Linked-color imaging (LCI) is a newly developed image-enhanced endoscopy technology. It relies on wave length optimization of three colors (red, green, and blue) to make the lesions appear fuller. LCI improves the visibility of colorectal adenomas and polyps and may increase the detection rate of lesions. In order to explore the clinical application value of Linked-color imaging endoscopy, we performed a prospective, randomized controlled trial to compare adenoma detection rate of Linked-color imaging endoscopy and indigo carmine chromoendoscopy.
Eligibility criteria
Qualifiers
Age between 45 and 85 years
Patients with a history of colorectal adenoma
Patients whose first-degree relatives have a history of colorectal cancer or colorectal adenoma
Patients with gastrointestinal symptoms (abdominal pain, bloody stool, chronic diarrhea or constipation, Unexplained anemia or weight loss;
Disqualifiers
Patients with pregnancy, inflammatory bowel disease, familial adenomatosis polyposis, suspected CRC; intestinal obstruction, coagulopathy
Patients with aspirin, clopidogrel or other anticoagulants/ antiplatelet drugs intake within 7 days
Patents previous colorectal resection
Patients with failed cecal intubation
Trial design
Treatments tested in this trial
- Chromoendoscopy with indigo carmine solution spray
- Linked-color imaging endoscopy
Treatment groups
352 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov