Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50-80
SponsorAssistance Publique - Hôpitaux de Paris
About this trial
This monocentric, non-interventional study (SELFSOC) investigates the relationship between self-awareness and social cognition in patients with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD).
The primary objective is to assess metacognitive efficiency related to social cognitive performance using a computerized facial emotion recognition task combined with confidence judgments. Metacognitive indices (including Mratio) will quantify the correspondence between subjective and objective performance.
Thirty-four participants (17 bvFTD, 17 AD; age 50-80; MMSE ≥20) will complete two study visits involving tasks assessing emotion recognition, theory of mind, and memory.
Eligibility criteria
Qualifiers
Diagnosis of possible or probable behavioral variant frontotemporal dementia according to the Rascovsky 2011 criteria (DLFTvc group) OR
Diagnosis of Alzheimer's disease according to the Jack 2018 criteria, including biomarkers (MA group)
Mini-Mental State Examination (MMSE) ≥ 20
Age: 50-80 years
Disqualifiers
Moderate to severe language disorders: Confrontation naming (DO 40 scale) ≤ 32
Inability to perform computerized tasks according to the investigator's opinion
Other neurological disorders (including epilepsy, Lewy body disease, vascular dementia)
Psychiatric comorbidities (bipolar disorder, schizophrenia, current major depressive episode)
Trial design
Treatments tested in this trial
- Computer-based facial expression recognition task
- Computerized affective task
- UCLA Structured Insight Interview
- Barber's Standardized Suggestibility Scale
Treatment groups
34 Participants
are divided into 2 treatment groupsSponsors and collaborators
Assistance Publique - Hôpitaux de Paris
Lead sponsor
Institut de psychologie
Collaborator
Université Paris Cité
Collaborator
Laboratoire Mémoire, Cerveau, Cognition
Collaborator
Source ClinicalTrials.gov