Lipiodol Prior to FET (LIFE)
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
AgeNot listed
SponsorMỹ Đức Hospital
About this trial
Lipiodol® flushing is an effective fertility treatment for women with unexplained infertility. It is speculated that the treatment effect could work through a direct effect of Lipiodol® on the endometrium. Given this direct effect on the endometrium, it is further hypothesized that Lipiodol® uterine treatment prior to In Vitro Fertilization (IVF)/ Intracytoplasmic Sperm Injection (ICSI) may also improve pregnancy rates. However, the effectiveness of Lipiodol® as an adjunct to IVF/ICSI treatment has not previously been examined in a well-powered and properly conducted randomised clinical trial.
Eligibility criteria
Qualifiers
Women undergoing IVF/ICSI
Having indications for freeze-all (day-3 or day-5)
Agree to have ≤ 2 frozen embryos transferred
TSH < 2.5 mIU/mL
Disqualifiers
Iodine allergy
History of salpingectomy or tubal ligation
History of using Lipiodol® within 6 months prior, starting from the screening time
At high risk of having Fallopian tube disorders (history of Chlamydia infection, history of pelvic inflammatory diseases, current endometriosis)
Trial design
Treatments tested in this trial
- Lipiodol® uterine treatment prior to IVF/ICSI
Treatment groups
784 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Mỹ Đức Hospital
Lead sponsor
Guerbet
Collaborator
Source ClinicalTrials.gov