Lipopolysaccharide Adsorption (Efferon LPS) in Patients With Thermal Burns
ConditionBurns
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorEfferon JSC
About this trial
This observational pilot study aims to establish criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS device in adult patients with burn injury. Participants will be prospectively enrolled into the treatment group and compared with a retrospectively selected control group. Each patient in the treatment group will undergo two hemoadsorption sessions, each lasting 6-12 hours, with a 24 hours interval between sessions. The procedures may be performed in combination with hemofiltration or hemodiafiltration at the investigator's discretion.
Eligibility criteria
Qualifiers
Thermal burn of Ⅱ and Ⅲ severity with a lesion area of 40% or more (ICD-10: T20-T25, T29)
Burn disease in the stage of acute toxemia or septicemia
Frank Index ≥ 90 (Frank Index quantifies burn severity based on the depth and total surface area of the skin lesion)
The patient's condition allows for Efferon LPS therapy for at least 6 hours
Disqualifiers
Isolated thermal inhalation injury
Charlson Comorbidity Index > 8
Dementia
End-stage renal failure
Trial design
Treatments tested in this trial
- Efferon LPS
Treatment groups
15 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov