LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Maryland, Baltimore
About this trial
The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas.
Eligibility criteria
Qualifiers
Patients with radiographic evidence of suggestive of a primary high-grade glioma
Brain MRI with contrast demonstrates an enhancing mass within 60 days prior to registration. Patient must be deemed a candidate for LITT from MRI by Neurosurgery in order to be eligible.
History and physical including neurological exam within 30 days prior to registration
Karnofsky performance status ≥50% within 30 days prior to registration
Disqualifiers
Patients that are not surgical candidates for stereotactic biopsy or laser ablation
History or presence of serious uncontrolled ventricular or significant arrhythmias.
Any of the following within 6 months prior to registration: myocardial infarction, severe/unstable angina, coronary artery bypass graft, congestive heart failure, cerebrovascular accident, transient ischemic attack , pulmonary embolism
Infratentorial tumor or evidence of leptomeningeal spread
Trial design
Treatments tested in this trial
- LITT
- Hypofractionated Radiation Therapy
Treatment groups
32 Participants
are divided into 1 treatment groupSponsors and collaborators
University of Maryland, Baltimore
Lead sponsor
Keep Punching Foundation
Collaborator
Source ClinicalTrials.gov