The study hypothesis is that liver transplantation after selective internal radiation therapy (SIRT) and chemotherapy would improve 3-year overall survival in patients with locally advanced (unresectable but non-metastatic) intrahepatic cholangiocarcinoma.
It is planned to include 36 patients with locally advanced intrahepatic cholangiocarcinoma, not eligible for initial surgery and without metastases. Participants will be recruited from care facilities in France.
Patient aged 18 to 65
Uni or pauci nodular (≤ 5 lesions (all lesions are counted, even those less than 1 cm))
Without extrahepatic or lymph node involvement
Technically unresectable R0 according to an expert panel
Extrahepatic, vesicular or perihilar cholangiocarcinoma
Tumor infiltration of more than 50% of the liver
Mixed cholangiocarcinoma, hepatocellular carcinoma, fibrolamellar carcinoma
Previous treatment for CCI