LIving BEtteR With asThma studY:: A Multimodal Intervention to Address Multimorbidity in Difficult Asthma
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorUniversity of Southampton
About this trial
Multimorbidity is a significant issue for many patients with difficult asthma. With patients, we have co-designed a multimodal intervention comprising prescribed exercise, dietary support, breathing pattern retraining and behaviour change to target multimorbidity in difficult asthma
Eligibility criteria
Qualifiers
clinical diagnosis of difficult asthma as defined by BTS steps 4-5 and
enrolled in WATCH or meet WATCH inclusion criteria.
Demonstration of suboptimal symptom control through an ACQ ≥ 1.5 at enrolment
Normal lung function or mild/moderate airflow obstruction at baseline (FEV1>50% predicted)
Disqualifiers
Intercurrent exacerbation or exacerbation within 4 weeks prior to enrolment in study requiring treatment with oral corticosteroids and/or antibiotics. Note participants can be rescreened 4 weeks post exacerbation if they had not commenced the study
Initiation of biologic treatment within 6 months prior to recruitment or during study participation
Investigator determined significant change in regular asthma medication in the 12 weeks preceding or during trial period
Other medical or psychiatric conditions (including cognitive decline) limiting ability to exercise or that may in the opinion of the study clinician carry inherent risk for exercise
Trial design
Treatments tested in this trial
- Behaviour change
- Dietary support
- Breathing pattern retraining
- Exercise training
Treatment groups
30 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
University of Southampton
Lead sponsor
University Hospital Southampton NHS Foundation Trust
Collaborator
Source ClinicalTrials.gov