Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG)

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of California, Davis

About this trial

This is a phase 2 pragmatic study that evaluates the clinical benefit of continuing systemic therapy with the addition of locally ablative therapies for oligo-progressive solid tumors as the primary objective. The primary outcome measure is the time to treatment failure (defined as time to change in systemic failure or permanent discontinuation of therapy) following locally ablative therapy.

Eligibility criteria

Qualifiers

Cohort A: (Cohort removed in protocol version 4.0)

Cohort B: Small bowel

Cohort C: Pancreatic and ampullary, colorectal, and appendiceal

Cohort D: (Cohort removed in protocol version 4.0)

Disqualifiers

Medical comorbidities precluding locally ablative therapies.

History of treatment related toxicities that limit or prohibit application of locally ablative therapies.

Progressing intracranial lesions.

Trial design

Treatments tested in this trial

  • Ablative local therapy

Treatment groups

300 Participants
are divided into 1 treatment group

Sponsors and collaborators

University of California, Davis

Lead sponsor

National Cancer Institute (NCI)

Collaborator