About this trial
Subjects that have a diagnosis of OCD will participate in a clinical interview and cognitive tasks, during which they will be exposed to their individual OC stressors or will be asked to make decisions related to information value and quantity while measuring neural activity and filming facial reactions. This will assist investigators to look for biomarkers of that change. This study offers a unique opportunity to develop biomarkers for key domains of OCD, and other neuropsychiatric disorders, that are grounded in brain neurocircuitry at the individual-patient level.
Subjects will participate in a clinical interview (Day 1), and then tasks+EEG (Day 2). Day 1 will be 4 hours or less, and Day 2 will be 2.5 hours or less.
Eligibility criteria
Qualifiers
Diagnosis of OCD
Non-pregnant if female
Minimum score of 16 on Y-BOCS
Ability to provide informed consent
Disqualifiers
Those not meeting inclusion criteria listed above
Lifetime diagnosis of psychotic disorders such as schizophrenia
Alcohol or substance abuse/dependence within 6 months, excluding nicotine
Deemed at high risk of suicidal behavior or impulsivity
Trial design
Treatments tested in this trial
- Beads Task
- PROVOC Tasks
Treatment groups
Sponsors and collaborators
Baylor College of Medicine
Lead sponsor
Brown University
Collaborator
University of Pittsburgh
Collaborator
Butler Hospital
Collaborator